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KMID : 0438420070140020117
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Korean Journal of Bone Metabolism
2007 Volume.14 No. 2 p.117 ~ p.123
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Osteoimmunology: Interaction between Bone and Immune System
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Lee Soo-Young
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Abstract
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The discovery of the RANKL/RANK/OPG axis as the final effector of bone destruction has generated great expectations regarding the potential of some antagonists for the treatment of patients with various metabolic and inflammatory bone disorders. Bone destruction is mainly attributable to the abnormal activation of osteoclasts and studies on activation of osteoclasts by the immune system have converged in recent years under the banner of osteoimmunology. The emergence of the niche field of osteoimmunology represents a conceptual rethinking of multiple phenomena, relating biological events in the bone and the immune system. Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding. [Korean Journal of Bone Metabolism, 14(2): 117-123, 2007]
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KEYWORD
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RANKL, RANK, Osteoclast, T lymphocyte, Dendritic cell
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